The proportion of expressed genes (Supplementary Fig. 2B) that were also eGenes ranged between 0.9% (esophageal cancer) – 28.1% (thyroid cancer; median = 4.1%) with the highest proportion of eGenes/expressed genes in thyroid, prostate (22.0%), and ER + breast (15.0%) cancers (Fig. 1A). This evidence concerns the gene ESR1 and thyroid cancer.