Since the expression and trafficking of sortilin is affected by levels of insulin resistance (40, 57, 58), ER stress (40, 58), saturated fatty acids (39, 56, 61), glucose (50), oxidized LDL (12), and inflammatory cytokines (41, 56), it is likely that metabolic context influences the directionality by which sortilin affects LDL-C. Here, SORT1 is linked to Insulin resistance.