In addition to its role in CVD, a large body of work has established sortilin as a regulator of neuronal development and maintenance and in the pathogenesis of neurological and mood disorders, including Alzheimer’s disease, frontotemporal lobar degeneration, Parkinson’s disease, depression, and anxiety (please see refs. 21, 22, 23, 24 for excellent reviews on this topic). This evidence concerns the gene SORT1 and early-onset autosomal dominant Alzheimer disease.