In addition to the SNPs at the 1p13.3 CELSR2-PSRC1-SORT1 locus being strongly associated with circulating LDL-C levels, this locus is also associated with several contributors of CAD, including atherosclerosis and arterial calcification (17, 18, 229, 244, 246, 281, 282, 283, 284, 285, 286, 287, 288, 289, 290, 291, 292, 293). The gene discussed is PSRC1; the disease is coronary artery disorder.