Within a subanalysis of participants with prior AMI or IHD diagnosis (n = 112), absolute incidence rate of ACS was 1.54 (0.4–5.6) in the high (>50 mg/dl) Lp(a) group and further increased to 3.3 (0.7–14.9) in the elevated (30–50 mg/dl) Lp(a) group when compared with low (<30 mg/dl) reference group (supplemental Table S1). This evidence concerns the gene LPA and myocardial ischemia.