HLA-C and neoplasm: Furthermore, in addition to MHC-restricted conventional T cells, non-MHC–restricted T cells, defined as unconventional ones, are also implicated in spontaneous tumor immune-surveillance (Godfrey et al, 2010; Mori et al, 2016; Gorini et al, 2017; Lawand et al, 2017; Cortesi et al, 2018; Li et al, 2020).