CREB1 and hepatocellular carcinoma: To demonstrate that whether HDACis led translocation of CRT to the nucleus and further induced HCC apoptosis, we treated HCC cells with HDACis (10 μM of Apicidin or 3 μM of SAHA) and measured protein levels of the members of CaM/CaMKII/CREB signaling pathway in both the cytosolic and nuclear fractions.