In contrast, some studies observed downregulation of CRT in laryngeal squamous cell carcinoma lesions [47], endometrial cancer [48], vaginal and cervical carcinoma [49], and non-small-cell lung cancer [50]; expression of CRT is especially low in advanced human prostate cancer and ovarian serous carcinoma than that in benign tissue [51, 52]. The gene discussed is CALR; the disease is Familial prostate cancer.