The expression of phosphatase and tensin homolog (PTEN) [11], a tumor-suppressor gene, was decreased, while that of members of phosphoinositide 3-kinase (PI3K)-Akt pathway (a pro-survival protein) [10, 11] and EMT-like signaling (as a marker of metastatic) [12] was increased in HDACis-R cells than that in HDAC-sensitive cells. Here, PTEN is linked to neoplasm.