MALAT1, acting as an miR-20a sponge, induces Toll-like receptor 4 (TLR4) signal transduction, leading to inflammatory reaction of human gingival fibroblasts (HGFs).13 Plasmacytoma variant 1 (PVT1), located on human chromosome 8q24, was recently found to be involved in oral inflammatory diseases.17 Lei et al12 found that the PVT1 leve l was increased markedly in pulp tissues of pulpitis patients.12 However, there is still relatively little research on the role of PVT1 in the pathogenesis of pulpitis. Here, TLR4 is linked to pulpitis.