Pulpitis is an inflammatory reaction in dental pulp tissue, mainly caused by bacterial infection.20 At present, a large number of studies have showed that lncRNA is related to the pathological mechanism of oral inflammatory diseases, including pulpitis, periodontitis, and periapical periodontitis.18 In this study, we found that the level of PVT1 in saliva of patients with pulpitis increased, while the expression of miR-128-3p decreased. Here, PVT1 is linked to periapical periodontitis.