CDKN2B and nervous system neoplasm: This is also the case for people affected by melanoma along with nervous system tumors due to deletion of both CDKN2A and CDKN2B, with suggestions that inactivation of CDKN2A/B genes might be responsible for the melanoma phenotype, while loss of adjacent genes might contribute to the development of other neoplasms (Chan et al., 2017).