This is also the case for people affected by melanoma along with nervous system tumors due to deletion of both CDKN2A and CDKN2B, with suggestions that inactivation of CDKN2A/B genes might be responsible for the melanoma phenotype, while loss of adjacent genes might contribute to the development of other neoplasms (Chan et al., 2017). Here, CDKN2B is linked to melanoma.