In addition, a splicing variant in CDKN2A (NM_000077.4:c.151–1G>C), responsible for loss of p16INK4a and p14ARF has been reported in a number of families affected by multiple neoplasms, including nerve sheath tumors and melanomas (Petronzelli et al., 2001; Prowse et al., 2003; Sargen et al., 2016). This evidence concerns the gene CDKN2A and melanoma.