Particularly, germline whole gene deletions of CDKN2A and CDKN2B are known to be associated with familial syndromes predisposing to malignant melanoma as well as other nervous system tumors, including meningioma, astrocytoma, and schwannoma (Azizi et al., 1995; Bahuau et al., 1997, 1998; Chan et al., 2017; Kaufman et al., 1993). This evidence concerns the gene CDKN2A and melanoma.