NF1 and plexiform neurofibroma: A second NF1 hit, and consequent loss‐of‐function, has been documented in several NF1‐associated cancers (Boudry‐Labis et al., 2013; Uusitalo et al., 2016), in cutaneous and plexiform neurofibromas as well as in tissues from pigmentary nonneoplastic lesions such as cafè‐au‐lait macules (CALMs) (De Schepper et al., 2008).