BRCA1 and ovarian carcinoma: However, there is also evidence of mismatch between genetic results and therapies received, for example, unwarranted recommendation of risk-reducing salpingo-oophorectomy to patients without an elevated risk of ovarian cancer in the PROMPT study (30) and our prior work suggesting underuse of radiotherapy and overuse of chemotherapy among BRCA1/2 PV carriers (3).