By studying the effect of curcumin on high-fat and high-fructose diet (HFHFr)-induced NAFLD in C57BL/6 mice and mice hepatocytes, it has been reported that curcumin may prevent and treat NAFLD by targeting the liver X receptor-α (LXRα), which can transcriptionally regulate fatty acid biosynthesis [49]. The gene discussed is NR1H3; the disease is metabolic dysfunction-associated steatotic liver disease.