Thus, transfection of the BCPAP (papillary) and 850C (anaplastic) thyroid cancer cells with DDX19B (DEAD-Box Helicase 19B), NEMP1 (nuclear envelope integral membrane protein 1), PANK2 (pantothenate kinase 2) and UBALD1 (UBA-like domain containing 1) induced significantly larger transcriptomic alterations in the cells where these genes had higher GCH. The gene discussed is PANK2; the disease is thyroid gland carcinoma.