WFDC2 and ovarian cancer: To compensate for this, in 2009, Moore et al. described the risk of malignant ovarian cancer can be predicted by using ROMA (risk of malignancy) scores calculated from CA125 and human epididymis secretory protein 4(HE4) but Van Gorp et al. reported that the ROMA score is not superior for detecting ovarian cancer when compared to CA125 alone [6,7].