For AD, this can reflect the targeting of each of the two drug binding sites available for AChE, the PAS and the CS, as this produces efficacious cholinesterase inhibition and can confer additional treatment benefits including inhibition of Aβ aggregation and modulation of N-methyl-D-aspartic acid (NMDA) receptors [27,32,33,34,35]. The gene discussed is ACHE; the disease is Alzheimer disease.