The molecular activity prediction analysis showed that TQ inhibition of IL-6 significantly attenuated the levels of Akt, NF-kB Complex, Ap1, ERK 1⁄2 STAT5 a/b, PTGS2, PI3K Complex, XIAP, and estrogen receptor in atherosclerosis (Supplementary Figure S2). Here, ESR1 is linked to atherosclerosis.