circRNA SMARCA5 regulates the progression of cervical cancer through inhibiting miRNA-432 [43], circRNA_0067934 promotes invasion of HCC through modulating the axis of miR-1324/FZD5/Wnt/β-catenin [44], circRNA LPAR3 sponges miRNA-198 causing upregulation of MET gene expression, which facilitates oesophagal cancer invasion [45], circRNA PRKCI inhibits miRNA-545 and induces glioma cell progression [46], and circRNA ZNF609 reduces miR-186-5p levels leading to induction of YAP1 and AMPK pathways and prostate cancer growth [47]. The gene discussed is PRKCI; the disease is central nervous system cancer.