GRIN2B and COVID-19: In this study, we investigated the pathways-targets-antihistamines (PTA) network and observed that Loratadine, Fexofenadine, Triprolidine, Ebastine, Dimetindene, and Terfenadine had a valid correlation on GRIN2B target on the neuroactive ligand–receptor interaction (KEGG ID: hsa04080), representing significant alleviative effects for COVID-19.