We found that miR-22-3p/miR-149-5p mimic transfection upregulated the expression of PDCD4/TP53INP1 in QGY-7703, and we speculate that the regulation of this methylation level is different in normal hepatocytes and in hepatoma cells, resulting in an inhibitory effect on the proliferation and metastasis of hepatoma cells but not in normal hepatocytes. Here, TP53INP1 is linked to hepatocellular carcinoma.