SIX2 and lung cancer: PHACTR1 is a phosphatase 1 and actin regulator; its downregulation enhances metalloproteinase inhibitors (e.g., TIMP2—the inhibition of migration-associated MMP9 and MMP2) [72,73]; SIX2 is a transcription factor that promotes lung cancer cell stemness and epigenetically regulates E-cadherin [74], and SH3KBP1/CIN85 is linked to hypoxia signaling; HIF1α degradation is promoted in its absence (Figure 4) [75].