This impairs the anti-AML leukocyte activities of cytotoxic lymphoid cells, and IL2 production is downregulated; additionally, the stress associated with these events leads AMLs to release HMGB1 (high-mobility group box 1), the protein that triggers the production of IL1β in healthy leukocytes [42]. The gene discussed is HMGB1; the disease is acute myeloid leukemia.