HAVCR2 and acute myeloid leukemia: Acute myeloid leukemia cells (AMLs) express ADGRL1/LPHN1 (adhesion G protein-coupled receptor L1/latrophilin 1), which help to facilitate the secretion of galectin-9 (the immune suppressor that lacks a secretory domain) and TIM3 (T-cell immunoglobulin and mucin domain containing protein 3).