From genome-wide association studies (GWAS) and other studies for Sjögren’s syndrome, some genes have been identified as a potential risk to pSS including STAT4, TNFAIP3, IRF5, IL12A, BLK, CXCR5, and GTF2I, and MHC alleles [27,28]. The gene discussed is IRF5; the disease is Sjogren syndrome.