In accordance with a recent study by Kassem et al. [54] on the Egyptian CRC patients, we found that the four TP53 somatic mutations c.628C>T, c.448C>T, c.347G>A, and c.128G>A in our cohort are specific to the CRC group, which suggests that they play a key role in the CRC in the Egyptian population. Here, TP53 is linked to colorectal carcinoma.