The two AXIN2 mutations (c.2347G>T and c.1102G>A) were previously addressed as being associated with small cell lung and prostate cancers, respectively [16,30], while the FZD3 mutation (c.674dupT) was previously reported in oral squamous cell carcinoma (OSCC) [46]. This evidence concerns the gene AXIN2 and Familial prostate cancer.