In our CRC patients, we have detected seven PIK3CA somatic variants; out of these, five of them were likely to be novel (c.40C>A, c.42C>G, c.44T>G, c.2992T>C and c.2825A>G), and they were located on exons 2, 2, 2, 21, and 20, respectively. This evidence concerns the gene PIK3CA and colorectal carcinoma.