POLE and colorectal carcinoma: In the CRC group, TP53 (48%; 21 out of 45 CRC cases carrying somatic mutations), APC (32%; 14/45), KRAS (16%; 7/45), PIK3CA (16%; 7/45), MSH6 (14%; 6/45), FBXW7 (14%; 6/45), SMAD4 (14%; 6/45), ATM (11%; 5/45), FGFR3 (9%; 4/45), BRAF (7%; 3/45), and POLE (7%; 3/45) were the top mutated genes.