The present study reported six somatic mutations in the FBXW7 gene that were found associated with CRC: two were previously reported with CRC patients (c.1647delG, c.823C>T), a single mutation was previously reported with breast cancer but was not addressed with CRC before (c.167A>G), and another three likely novel mutations (c.1568C>A, c.1252dupA, c.1030T>C) [16,25,124]. This evidence concerns the gene FBXW7 and breast carcinoma.