Here, we studied the impact of TFCP on the serum parameters, including lipid profile, antioxidants, liver enzymes (ALT and AST), and the gene expression of inflammatory cytokines (IL-1β, HNF4α, TLR4, TNF-α, and IL-6) and lipid metabolism-associated genes (HMGCR, FABP, SREBP, ACC, and FAS) in the MCD-diet-induced NAFLD mice. Here, HMGCR is linked to metabolic dysfunction-associated steatotic liver disease.