Moreover, ZEB2 correlates with SMAD1 in 28 cancer types, SMAD2 in 27 cancer types, SMAD3 in 22 cancer types, SMAD5 in 28 cancer types, CTBP1 in 14 cancer types, and CTBP2 in 22 cancer types (Supplementary Table S3). Here, SMAD5 is linked to cancer.