TGFB1 and glaucoma: In glaucoma, miRNAs can regulate ECM metabolism by regulating TGF-β and can regulate stiffness by the accelerated maturation of ECM proteins, altering the trabecular meshwork (TM) contractile properties, thus accelerating or inhibiting TM cell senescence, or by modulating oxidative- and mechanical-stress-induced damage [20,22,38] in the cell/tissue(Table 1).