A genome-wide association study performed in 2007 by Thorleifsson and coworkers first showed that three single-nucleotide polymorphisms (SNPs) in the lysyl oxidase-like 1 (LOXL1) gene (rs1048661, rs1048661, and rs3825942) are strongly associated with a risk of XFG [5]. The gene discussed is LOXL1; the disease is exfoliation syndrome.