OXT and Anxiety: Accumulating evidence from sophisticated animal models suggests that some of the complex regulatory effects of OXT are critically mediated by interactions with other neurotransmitter systems such that animal models demonstrated that dopamine partly mediated OXT’s effects on pair bonding (Young and Wang, 2004) while the serotonin (5-HT) system critically mediated OXT’s regulatory effect in the domains of social reward and anxiety (Yoshida et al., 2009; Dölen et al., 2013; Lefevre et al., 2017).