Based on previous studies, we hypothesized that (1) OXT’s effects on the amygdala intrinsic networks are (partly) mediated by interaction with the 5-HT system and that a transient reduction in 5-HT signaling following ATD would attenuate OXT’s effect; and (2) given the role of OXT and 5-HT in stress processing and a high stress-sensitivity of the amygdala intrinsic networks (Sripada et al., 2012; Vaisvaser et al., 2013; Fan et al., 2015; Zhang et al., 2016; Feng et al., 2018), the identified pathways would be associated with levels of currently experienced stress exposure. The gene discussed is OXT; the disease is Jeune syndrome.