Amongst other mechanisms, during viral infection 3CL-pro contributes to the delay of host anti-viral innate immune response by cleaving or inactivating key elements of the Retinoic acid-inducible gene I (RIG-I) like receptors (RLRs)-mediated Type I interferon (INF-I) signalling pathway, which allows effective viral infection and contribute for disease progression and severity [15–17]. This evidence concerns the gene RIGI and viral infectious disease.