HMGB3 and colorectal carcinoma: CAFs could secret sEVs to CRC cells, thereby promoting the development and metastasis of CRC and participating in the therapeutic resistance of CRC cells.28,30 In this study, we reported that CAFs-derived sEV circN4BP2L2 accelerated CRC progression via regulating miR-664b-3p/HMGB3 expression, as well as activating the Wnt/β-catenin pathway.