HMGB3 and cancer: HMGB3 is involved in the progression of some cancers, such as esophageal squamous cell cancer, breast cancer and so on.36,37 HMGB3 has been demonstrated to play an oncogene role in CRC.38 miR-93 targeted regulated HMGB3 expression, and the repression effect of miR-93 on biological behavior of CRC cells could be counteracted by HMGB3 overexpression.39 In the current work, we proved that miR-664b-3p could directly target and negatively regulate HMGB3 expression (Figure 5).