MiR-664b-3p overexpression suppressed cell proliferation, migration, and invasion in colon cancer through restraining BUB3 protein expression.22 It was found here that miR-664b-3p overexpression drastically depleted cell proliferation, migration and tube formation abilities in LoVo cells and elevated cell apoptosis rate (Figure 6). This evidence concerns the gene BUB3 and colonic neoplasm.