We reported that CAFs-sEV circN4BP2L2 exerted an oncogene role and promoted cell proliferation, migration and tube formation abilities by up-regulating HMGB3 expression via recruiting miR-664b-3p, which might provide a novel insight for the mechanism of circN4BP2L2 in CRC development. This evidence concerns the gene HMGB3 and colorectal carcinoma.