CircRNAs, as endogenous RNA molecules for miRNA sponges, regulate multiple biological processes by directly binding to targeted miRNAs.33,34 For example, circFMN2 promoted CRC cell proliferation via regulating the miR-1182/hTERT axis.35 As demonstrated by Shang A, et al., CRC-derived exosome circPACRGL could facilitate the progression of CRC cells through regulating the miR-142-3p/miR-506-3p-TGF-β1 pathway.15 In our work, starbase was used to predict the targeted miRNAs of circN4BP2L2, and Starbase, TargetScan and miRWalk were used to predict the targeted miRNAs of HMGB3. This evidence concerns the gene HMGB3 and colorectal carcinoma.