VWF and aortic stenosis: On the basis of these observations, we designed the prospective METHYSTROKE study (Identification of Epigenetic Risk Factors for Ischemic Complication During the TAVR Procedure in the Elderly; URL: https://www.clinicaltrials.gov; Unique identifier: NCT02972008) to investigate whether TAVR performed in patients with symptomatic AS and acquired VWF defect is associated with the occurrence of new CMBs.