The current study including 84 patients with severe symptomatic AS undergoing transfemoral TAVR with preprocedural and postprocedural MRI performed 3 days apart demonstrates that (1) ≈1 patient out of 4 has CMBs before TAVR and nearly 1 out of 4 develops new CMBs after TAVR (23% [95% CI, 14%–33%]) and (2) longer fluoroscopy time and an acquired VWF multimer defect (in particular when this defect persists at the end of the procedure) are associated with the occurrence those new postprocedural CMBs. The gene discussed is VWF; the disease is aortic stenosis.