According to the relevant studies about the impacts of circRNA on sepsis-associated diseases, circ_0114428 was confirmed to regulate sepsis-induced kidney injury by targeting the miR-495-3p/CRBN axis [14], and circular RNA TLK1 promotes sepsis-associated AKI by modulating inflammation and oxidative stress through miR-106a-5p/HMGB1 axis [15]. The gene discussed is HMGB1; the disease is Sepsis.