In addition, in intracranial hemorrhage (ICH) mice, AC-YVAD-CMK (a selective inhibitor of caspase-1) inhibited pyroptosis and neuroinflammation by suppressing caspase-1 activation and IL-1β production, ultimately promoting the recovery of neurological function after ICH (Lin et al., 2018). Here, CASP1 is linked to intracranial hemorrhage.