NLRP3 and major depressive disorder: In animal models of stress-induced depression and depressed patients, antidepressants, including fluoxetine, paroxetine, and mianserin, induce autophagy, thereby promoting a decrease in serum IL-1β and IL-18 levels and inhibiting the expression of NLRP3 and IL-1β (Alcocer-Gómez et al., 2017).