Altogether, these case reports allow to make some initial statements: (i) MORC2 mutations are associated with a spectrum of neuropathies; (ii) all the mutations are localized in the catalytic domain of the protein, suggesting that MORC2 ATPase function is important; (iii) some mutations cause the same clinical feature in the different individuals, although the degree of severity remains variable. The gene discussed is DNAH8; the disease is neuropathy.