However, after a challenge with bacterial lipopolysaccharide (LPS) (Velasco-Estevez et al., 2020b) or in an aging transgenic mouse model of Alzheimer’s disease (Velasco-Estevez et al., 2018) the expression of Piezo1 increases, contributes to the inflammatory response of astrocytes and further amplifies the amyloid plaque-induced upregulation of Piezo1 in astrocytes. Here, PIEZO1 is linked to early-onset autosomal dominant Alzheimer disease.