During adult cardiac surgery with CPB, corticosteroids prophylaxis was associated with increased risks of myocardial infarction (OR: 1.19, 95% CI: 1.05–1.35; p = 0.008, I2 = 0%) (Figure 2) and insulin infusion (OR: 1.91, 95% CI: 1.18–3.11; p = 0.009, I2 = 46%) (Supplementary Figure S1), with no obvious improvement in mortality (OR: 0.86, 95% CI: 0.71–1.03; p = 0.10, I2 = 0%) (Figure 3). Here, INS is linked to myocardial infarction.