INS and infection: During pediatric cardiac surgery with CPB, corticosteroids prophylaxis was associated with a decreased CPB time (MD: −11.54 min, 95% CI: −14.32, −8.75 min; p < 0.001, I2 = 5%) and an increased insulin infusion (OR: 3.68, 95% CI: 1.53–8.84; p = 0.004, I2 = 48%), but did not significantly influence mortality, kidney injury, ECMO use, postoperative infection, mechanical ventilation time, and ICU length of stay [LOS] (Tables 2, 3 and Supplementary Figures S36–S43).