UMOD and autosomal dominant medullary cystic kidney disease with or without hyperuricemia: Some mutations in UMOD can cause autosomal dominant tubulointerstitial kidney disease (ADTKD), leading to the acummulation of mutant uromodulin in the endoplasmic reticulum of tubular cells, causing decresed levels of urinary uromodulin and tubulointerstitial injury.