Some observations point to Cavin-1 promoting tumor migration in pancreatic cancer cells by cooperating with caveolin-1 but inhibiting invasiveness and metastasis by matrix metalloproteinase 9 (MMP-9) production, neutralizing CAV1 tumor-promoting properties in PC3 pancreatic cancer cells (11, 12). Here, MMP9 is linked to familial pancreatic carcinoma.