We then used the GEPIA and BloodSpot database to validate the unexpected result and found that high CAVIN2 expression was significantly associated with poorer OS in leukemia (p is 0.037 and 0.022 individually), but the trend was not significant for CAVIN1, CAVIN3 and CAVIN4 (Figures 3B,C). This evidence concerns the gene CAVIN3 and leukemia.