In the study of Torralba-Cabeza et al. that included 178 subjects (89 Fabry patients and 89 healthy controls), Cystatin-C concentration was found to be a superior and more sensitive marker than serum creatinine for detection of early renal dysfunction and small decreases in glomerular filtration in both males and female Fabry patients (114). Here, CST3 is linked to Abnormal renal physiology.