This panel must contain not only all genes that cause BS and Gitelman syndrome but also genes that overlap phenotypically with BS and should be considered in differential diagnosis with BS: SLC12A1, KCNJ1, CLCNKB, CLCNKA, BSND, MAGED2, SLC12A3, CASR, KCNJ10, SLC26A3, CLDN10, SCNN1A, SCNN1B, SCNN1G, NR3C2, HSD11B2, CYP11B1, CLCN2, KCNJ5, and CACNA1H (1). This evidence concerns the gene SCNN1B and Bloom syndrome.