TNF and obesity due to melanocortin 4 receptor deficiency: Obesity is a chronic relapsing disorder resulting from excessive fat deposits that stimulate the release of inflammatory mediators such as tumour necrosis factor α (TNF-α) and interleukin 6 (IL-6), which predispose obese individuals to a proinflammatory state [1]; furthermore, obesity represents a substantial risk for type 2 diabetes, dyslipidaemia, ischemic heart disease, and other comorbidities [2].