Zhu et al. (2016) demonstrated that sterol regulatory-element binding protein –1-mediated transcription of lipogenic genes and lipid production are essential for breast cancer development. However, Coleman et al. (2021) reported that folate deprivation or anti-folate therapy inhibits triple-negative breast cancer cell growth by inducing mitochondrial dysfunction. The gene discussed is SREBF1; the disease is triple-negative breast carcinoma.