IL1B and Keratoconjunctivitis sicca: The importance of IL-1 as an AMP stimulant was highlighted in the murine model of experimental dry eye, where IL-1 receptor deficient mice demonstrated non-existent to decreased levels of mBD2 in cornea and conjunctiva when compared to wild type mice (Narayanan et al., 2008) Interestingly, local application of a newly discovered subfamily of cytokines, IL-36γ, stimulated expression of mBD3 in murine corneas while simultaneously inhibiting IL-1β (Gao et al., 2018).