In addition, proteome functional annotation analyses and Phyre2 structure modeling of open reading frames located close to several potential AMPs identified (1) putative homologs and structural orthologs of proteases with potential roles in AMP leader peptide cleavage and activation and (2) ABC transporters that may mediate export of the mature active treponemal AMPs to the external host environment during infection. This evidence concerns the gene ABCG2 and infection.