Since abnormal alpha-synuclein aggregation induced by impaired proteasomal and lysosomal function is a vital pathological feature in PD (Chu et al., 2009; Hoffmann et al., 2019), further studies are warranted to test whether impairment of protein degradation pathway mediates the association between Blautia genus and alpha-synuclein clearance in PD. The gene discussed is SNCA; the disease is Parkinson disease.