TP53 and neoplasm: The tumour suppressor functions of p53 are achieved via cell cycle arrest, repair of DNA, senescence, and apoptosis.12, 13, 14, 15 Researchers have marked the aberrations in the p53 gene, resulting in accumulation of p53 protein in the tissue samples of oral cancerous and precancerous lesions, which in turn leads to induction of p53 autoantibodies in circulation as a part of humoral immune response.16, 17, 18, 19