COG2 and ischemic stroke: In 2019, 8.54 million people died of ischemic heart disease (IHD) worldwide, and the death of 3.78 million of them was related to increased plasma levels of LDL-C; 2.73 million people died of ischemic stroke, and the death of 0.61 million of them was related to high plasma levels of LDL-C [3].