JAK2 and cancer: The further KEGG results presented that those five flavonoids mainly targeted the main 15 proteins, such as MAPK14, MET, HRAS, HSP90, and JAK2/3, which involved mainly in regulating IAV-related signaling, including pathways in cancer, MAPK signaling pathway, lipid and atherosclerosis, chemical carcinogenesis ROS, PI3K-Akt signaling pathway, proteoglycans in cancer, and viral carcinogenesis (Figure 4).