The miR-328, previously identified as crucial regulators in atherosclerosis, has been proved to protect the vascular endothelial cells against deleterious cellular events including cell viability, migration, invasion, apoptosis, and autophagy by targeting forkhead box protein O4 and the high-mobility group box 1 (HMGB1) (22, 23). This evidence concerns the gene HMGB1 and atherosclerosis.