AVP and Hypertension: Although an increased vascular sensitivity to ADH has been reported in several experimental models of hypertension, such as the spontaneously hypertensive (SHR) (43), the deoxycorticosterone (DOC)-salt hypertensive (44), the Dahl salt-sensitive hypertensive (45), the New Zealand genetically hypertensive rats (46), ADH V1a receptor-selective antagonism lowers BP in mineralocorticoid-related hypertension (47) but not in renovascular hypertension (48).