The involvement of V2 receptors in ADH’s potential role in the development of hypertension was also conflicting and inconclusive, observing in fact both a reduction in BP after the administration of V2 receptor antagonist administration OPC 31260 to young male SHR in the prehypertensive phase (57), but also the lack of a hypotensive effect in young SHR but a significant hypertensive effect in the adult SHR (58). The gene discussed is AVP; the disease is Hypertension.