The current study suggested the LINC00702–miR-181b-5p–SPP1 axis could participate in the development and progression of CAVD and that LINC00702, LINC00092, SPP1, TREM1, TLR8, SDC1, GPM6A, and CNTN1 might be the hub molecules associated with CAVD. Here, SPP1 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.