A cross-sectional study of 236 patients demonstrated that detection of different antibody isotypes to MAA adducts were associated with separate CAD states; for example, higher levels of anti-MAA IgM and IgG antibodies were associated with acute myocardial infarction, whilst CABG patients had comparatively higher anti-MAA IgA antibodies (30). This evidence concerns the gene CD40LG and coronary artery disorder.