IGFBP2's role in CVD may be multifactorial, with associations also shown with intima-media thickness and myocardial infarction, while data on cardiometabolic endpoints such as obesity and metabolic syndrome paradoxically show negative correlations with IGFBP2 in literature (78–80). The gene discussed is IGFBP2; the disease is obesity due to melanocortin 4 receptor deficiency.