Recent studies also revealed the relationship between ALI and TLR4/NF-κB signaling pathway through LPS/D-GalN-induced ALI in mice, but the hepatoprotective mechanism of autophagy in combination with TLR4/NF-κB has not been yet explored (Chen et al., 2021; Jia et al., 2018). This evidence concerns the gene NFKB1 and acute respiratory distress syndrome.