Accordingly, the gene expression of TLR4 was elevated in the HF group and FRT4 intervention decreased the gene expression of TLR4 and IL-6, which is in line with the reports that IL-6 was diminished by the treatment with L. reuteri V3401 in adults with metabolic syndrome and L. plantarum HFY09 alleviated inflammation by decreasing the levels of pro-inflammatory factors IL-6, IL-1β, and TNF-α in ethanol-induced liver injury in mice (31, 32). Here, IL1B is linked to metabolic syndrome.